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human_metabolic_physiology_study · 2014

Xenin-25 delays gastric emptying and reduces postprandial glucose levels in humans

Chowdhury S|Reeds DN|Crimmins DL|Patterson BW|Ladenson JH|Polonsky KS|Wice BM · Journal of Clinical Endocrinology and Metabolism
moderatePMID · 24356886Verified
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Plain-English summary

Xenin-25 slowed gastric emptying and reduced post-meal glucose excursions in a small human study.

Population
Adults undergoing metabolic testing
Intervention
Exogenous xenin-25 during meal testing
Outcomes measured
Gastric emptying|Postprandial glucose|Insulin secretion|Symptoms
Key findings
Demonstrated acute gastrointestinal and metabolic activity.
Limitations
Small sample|Acute administration|Gastrointestinal adverse effects|No long-term outcomes
Risk of bias
Moderate because of the short physiological design.
Citation
Chowdhury S|Reeds DN|Crimmins DL|Patterson BW|Ladenson JH|Polonsky KS|Wice BM (2014). Xenin-25 delays gastric emptying and reduces postprandial glucose levels in humans. Journal of Clinical Endocrinology and Metabolism
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