Animal study· 2001
Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment
Heffernan MA; Thorburn AW; Fam B; Summers R; Conway-Campbell B; Waters MJ
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
- PubMed
- 11673763
- Evidence level
- preclinical
- Verification
- verified
Summary
Seminal 2001 preclinical study establishing that AOD9604 reduces body-weight gain and increases fat oxidation in ob/ob mice comparably to hGH, yet without inducing hyperglycaemia, without suppressing insulin, and without binding the hGH receptor or driving cell proliferation — supporting the "pro-hormone" fragment concept for AOD9604.
Limitations
Mouse model only (no human); per-arm sample sizes and dosing detail not given in the abstract; sponsor/conflict data not in abstract; older methodology (2001).