Animal study· 2015
Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model
Kwon DR; Park GY
Annals of clinical and laboratory science
- PubMed
- 26275694
- Evidence level
- preclinical
- Verification
- verified
Summary
Randomised 4-arm rabbit collagenase-OA study (n=32) showing that intra-articular AOD9604 alone and combined with hyaluronic acid reduced cartilage-degeneration scores and lameness compared with saline; the AOD9604+HA combination outperformed either monotherapy in histology and lameness.
Limitations
Small preclinical rabbit model (32 animals, ~8 per arm); short follow-up (8 weeks); blinding of assessors not described in abstract (uncertainty, not a positive blinding defect); single-centre; no long-term joint safety data. No commercial-COI signal in abstract.