Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats
Kolik LG; Nadorova AV; Antipova TA; Kruglov SV; Kudrin VS; Durnev AD
Bulletin of experimental biology and medicine
- PubMed
- 31625062
- Evidence level
- preclinical
- Verification
- verified
Summary
Kolik et al. 2019 (Bull Exp Biol Med) report that in outbred rats receiving 30 weeks of chronic ethanol exposure, 7 days of Selank IP produced a cognitive-stimulating effect in non-ethanol rats and prevented ethanol-withdrawal-induced memory disturbance in the object-recognition test, and prevented an ethanol-induced increase in hippocampal + frontal-cortex BDNF.
Limitations
Rat model only; per-arm sample size implied but not stated in the abstract (uncertainty, not a defect); short (7-day) Selank dosing window; single behavioural readout; single dose (0.3 mg/kg) with no dose-response; blinding of observers not described (uncertainty). No commercial-COI signal in abstract.