Thymosin β4 and Actin: Binding Modes, Biological Functions and Clinical Applications
Ying Y; Lin C; Tao N; Hoffman RD; Shi D; Chen Z
Current protein & peptide science
- PubMed
- 36464872
- Evidence level
- review
- Verification
- needs_review
Summary
Ying et al. 2023 (Curr Protein Pept Sci) review of Tβ4-actin binding modes (1:1 G-actin sequestration) and biological consequences (inflammation, tumour-metastasis regulation, angiogenesis, wound healing, hair-follicle regeneration, nervous-system development, bone/tooth formation) with broad claimed medicinal applications across kidney, liver, heart, brain, intestine, hair loss, skin trauma, and cornea repair.
Limitations
Broad and largely unqualified therapeutic-application claims in the abstract; publisher (Bentham Science) known for lower average editorial rigour than top-tier reviews; no meta-analytic quantification; the review's utility depends on whether the underlying primary references are individually solid.