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Evidence Library
laboratory_and_clinical_cosmetic_study · 2025

Acetyl Dipeptide-31 Amide: A Novel Cosmetic Anti-Inflammatory Peptide That Demonstrates Anti-Aging, Firming, and Lifting Benefits

Edison BL|Parsa R|Dufort M|et al. · Journal of Drugs in Dermatology
weakPMID · 39761149Verified
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Plain-English summary

Early testing suggests that topical AP31 may improve visible firmness and signs of skin ageing, but the evidence base is still small.

Population
Adults with visible facial skin ageing
Intervention
Topical cosmetic formulations containing acetyl dipeptide-31 amide
Outcomes measured
Inflammatory markers|Extracellular-matrix markers|Firmness|Lifting|Visible signs of ageing|Tolerability
Key findings
Reported anti-inflammatory activity and improvements in selected cosmetic endpoints.
Funding & disclosures
Commercial affiliations and product-development involvement should be considered when interpreting the findings.
Limitations
Small early evidence base|Limited independent replication|Cosmetic endpoints|Potential formulation and sponsor confounding
Risk of bias
High — early product-associated evidence with limited independent confirmation.
Citation
Edison BL|Parsa R|Dufort M|et al. (2025). Acetyl Dipeptide-31 Amide: A Novel Cosmetic Anti-Inflammatory Peptide That Demonstrates Anti-Aging, Firming, and Lifting Benefits. Journal of Drugs in Dermatology
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