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controlled_human_pharmacology_study · 1995

Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man

Frieboes RM, Murck H, Maier P, Schier T, Holsboer F, Steiger A · Neuroendocrinology
lowPMID · 7617137Verified
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Plain-English summary

GHRP-6 stimulated growth hormone but also affected ACTH, cortisol and sleep, showing that its effects are not limited to muscle-related pathways.

Population
Healthy adult men
Intervention
Acute administration of GHRP-6 under laboratory sleep-study conditions
Outcomes measured
Growth hormone|ACTH|Cortisol|Sleep architecture
Key findings
GHRP-6 stimulated growth hormone and also increased ACTH and cortisol while altering sleep-related measures.
Limitations
Small sample, acute administration and hormone or sleep endpoints only. The study does not establish long-term efficacy or safety.
Risk of bias
High — small experimental study with limited duration and surrogate outcomes.
Citation
Frieboes RM, Murck H, Maier P, Schier T, Holsboer F, Steiger A (1995). Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man. Neuroendocrinology
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