preclinical_and_ex_vivo_study · 2000
Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism
Heffernan MA, Thorburn AW, Fam B, Summers R, Conway-Campbell B, Waters MJ, Ng FM · American Journal of Physiology-Endocrinology and Metabolism
preclinicalPMID · 10950816Verified
Plain-English summary
A related growth hormone fragment affected fat metabolism in animals and isolated human fat tissue, but this is not proof that HGH fragment 176-191 produces meaningful fat loss in people.
Population
Rodent obesity models and human adipose tissue samples
Intervention
AOD-9401 exposure
Outcomes measured
Body weight in mice|Lipolysis|Antilipogenesis|Lipid metabolism
Key findings
The fragment showed lipid-metabolism activity in experimental systems, supporting further research rather than clinical use claims.
Funding & disclosures
Commercial development interests were associated with the AOD programme.
Limitations
Not a clinical efficacy trial, used a related fragment rather than necessarily identical commercial HGH fragment 176-191, and relied on animal and ex vivo outcomes.Risk of bias
High for human clinical inference — preclinical and ex vivo design with no patient outcomes.Citation
Heffernan MA, Thorburn AW, Fam B, Summers R, Conway-Campbell B, Waters MJ, Ng FM (2000). Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism. American Journal of Physiology-Endocrinology and Metabolism
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