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PeptiBrief
Preclinical mechanistic study· 2016

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor RXFP1

Hossain MA|Kocan M|Yao ST|Royce SG|Nair VB|Siwek C|Patil NA|Harrison IP|Rosengren KJ|Selemidis S|Summers RJ|Sasson S|Bathgate RAD|Wade JD

Chemical Science

DOI
10.1039/c6sc00688a
PubMed
30155023
Evidence level
preclinical
Verification
verified

Summary

The study described design and preclinical characterisation of the single-chain relaxin mimetic B7-33.

Limitations

Preclinical only|No human pharmacokinetic or efficacy data|Complex biased signalling

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