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Evidence Library
controlled_human_pharmacology_study · 2005

Growth hormone releasing peptide-2, like ghrelin, increases food intake in healthy men

Laferrère B, Abraham C, Russell CD, Bowers CY · Journal of Clinical Endocrinology and Metabolism
lowPMID · 15699539Verified
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Plain-English summary

GHRP-2 increased food intake as well as growth hormone in a very small study, highlighting that it is not a selective muscle-building treatment.

Population
Healthy lean adult men
Sample size
7
Intervention
Subcutaneous GHRP-2 infusion compared with control conditions
Outcomes measured
Food intake|Growth hormone|Appetite-related responses
Key findings
GHRP-2 increased food intake and stimulated growth hormone secretion.
Limitations
Only seven participants, acute administration and surrogate outcomes prevent conclusions about long-term benefits or safety.
Risk of bias
High — extremely small sample and short-duration experimental design.
Citation
Laferrère B, Abraham C, Russell CD, Bowers CY (2005). Growth hormone releasing peptide-2, like ghrelin, increases food intake in healthy men. Journal of Clinical Endocrinology and Metabolism
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