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PeptiBrief
Evidence Library
narrative_review · 1999

Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency

Prakash A, Goa KL · BioDrugs
low_to_moderatePMID · 18031173Verified
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Plain-English summary

Older evidence suggests sermorelin can stimulate growth hormone and may increase growth velocity in some children, but modern evidence is limited and it is not established as an anti-ageing or bodybuilding therapy.

Population
Children evaluated for or diagnosed with idiopathic growth hormone deficiency
Intervention
Intravenous diagnostic dosing or daily subcutaneous sermorelin
Outcomes measured
Growth hormone response|Growth velocity|Tolerability
Key findings
Sermorelin was useful as a provocative diagnostic agent and limited data suggested growth benefit in some children.
Limitations
Older review, limited treatment trials and little evidence for current off-label adult uses.
Risk of bias
Moderate to high — narrative review based on a limited historical evidence base.
Citation
Prakash A, Goa KL (1999). Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs
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