narrative_review · 2021
Stable Gastric Pentadecapeptide BPC 157 and Wound Healing
Seiwerth S, Milavic M, Vukojevic J, et al. · Frontiers in Pharmacology
moderateDOI · 10.3389/fphar.2021.627533PMID · 34267654Verified
Plain-English summary
A review of experimental studies reporting tissue-repair effects of BPC-157, mainly in rodents; it does not establish clinical effectiveness in people.
Population
Predominantly rats and mice across the reviewed studies
Intervention
BPC-157 administered by several experimental routes and dose regimens
Outcomes measured
Wound closure, tissue histology, biomechanical strength, vascular responses and healing-related endpoints
Key findings
The reviewed preclinical studies generally reported faster or improved healing outcomes, but clinical effectiveness remains unconfirmed.
Funding & disclosures
The article reports academic affiliations; potential author-network and publication-bias limitations remain relevant.
Limitations
Evidence is predominantly preclinical and much of the literature comes from a limited number of closely associated research groups; controlled human efficacy data are lacking.Risk of bias
High — narrative review with substantial reliance on studies from the originating research network and possible publication bias.Citation
Seiwerth S, Milavic M, Vukojevic J, et al. (2021). Stable Gastric Pentadecapeptide BPC 157 and Wound Healing. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2021.627533
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