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PeptiBrief
Metabolic and neuroendocrine

Dual GIP and GLP-1 receptor signalling

Simultaneous agonism of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptors affects glucose-dependent insulin secretion, appetite regulation, gastric function and energy balance.

Biological pathway

GIP receptor and GLP-1 receptor agonism → Gs protein signalling → increased cyclic AMP in responsive tissues → coordinated metabolic and appetite-related effects.

Evidence summary

Tirzepatide has established dual-receptor pharmacology and randomized clinical evidence for glycaemic control and chronic weight management.

Limitations

The relative contribution of GIP receptor activation versus GLP-1 receptor activation to individual clinical outcomes remains incompletely resolved.

Peptides linked to this mechanism

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