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PeptiBrief
Mechanism

Erythropoietin innate repair receptor signalling

Selective activation of the tissue-protective erythropoietin receptor complex without clinically meaningful erythropoiesis.

Canonical mechanism for ARA-290 and cibinetide.
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Biological pathway

ARA-290 is designed to activate the innate repair receptor, a heteromeric complex associated with anti-inflammatory, cytoprotective and tissue-repair signalling.

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Evidence summary

Small phase 2 studies in sarcoidosis and diabetic neuropathy report symptom and small-fibre signals, but confirmatory evidence is limited.

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Limitations

The receptor model and clinical relevance remain under investigation; findings cannot be generalised to unregulated products.
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Peptides linked to this mechanism

ARA-290

An investigational erythropoietin-derived peptide studied for neuropathic pain and tissue protection.

Confidence · supported
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