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PeptiBrief
Dermatology

Keratinocyte mechanics and structural-protein modulation

Changes in keratinocyte mechanical properties and expression of structural skin proteins.

Biological pathway

Cell-culture studies report altered actin organisation, stiffness and expression of genes associated with collagen and elastin regulation.

Evidence summary

Peer-reviewed in vitro work supports biological activity of acetyl tetrapeptide-2 in keratinocytes.

Limitations

Cell stiffness and gene-expression findings do not prove visible anti-ageing benefits in humans.

Peptides linked to this mechanism

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