Lipolysis and fat oxidation
Mobilisation and oxidation of stored triglycerides from adipose tissue.
Biological pathway
Hormonal and adrenergic signals activate lipases and fatty-acid oxidation pathways in adipose and other metabolic tissues.
Evidence summary
AOD-9604 has preclinical evidence for lipolytic effects, while human clinical benefit remains unestablished.
Limitations
Peptides linked to this mechanism
An investigational modified growth-hormone fragment that reached obesity trials but did not become an approved weight-loss medicine.
HGH Fragment 176-191 is an investigational peptide, analogue or research construct with evidence ranging from mechanistic studies to limited human trials.
Irisin Mimetic is an investigational peptide, analogue or research construct with evidence ranging from mechanistic studies to limited human trials.
Nesfatin 1 is an endogenous signalling peptide with physiological relevance; therapeutic administration remains molecule- and indication-specific.
Spexin is an endogenous signalling peptide with established or emerging physiological relevance.
Leptin Fragment is an investigational peptide, analogue or research construct with evidence ranging from mechanistic studies to limited human trials.
Fgf21 Analogue is an investigational peptide, analogue or research construct with evidence ranging from mechanistic studies to limited human trials.