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PeptiBrief
Neuroendocrine, Vascular and Immune

VPAC receptor signalling

Activation of VPAC1 and VPAC2 G-protein-coupled receptors by vasoactive intestinal peptide.

Biological pathway

VPAC receptor activation raises cyclic AMP and regulates vasodilation, smooth-muscle tone, glandular secretion, immune signalling and neuronal communication.

Evidence summary

Human vascular, pulmonary and migraine-provocation studies confirm strong physiological activity.

Limitations

VIP is rapidly degraded, can cause hypotension and headache, and has not shown broad established efficacy across proposed indications.

Peptides linked to this mechanism

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