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PeptiBrief
Gastrointestinal and Metabolic

Xenin and neurotensin receptor signalling

Xenin-mediated gastrointestinal and metabolic signalling associated mainly with neurotensin receptor pathways.

Biological pathway

Xenin-25 influences gastrointestinal motility, gastric emptying and incretin-linked insulin secretion, with neurotensin receptor 1 implicated in several experimental systems.

Evidence summary

Small human physiology studies demonstrate effects on gastric emptying, intestinal motility and GIP-mediated insulin secretion.

Limitations

The receptor biology is not fully resolved in humans, and clinical studies are small and short term.

Peptides linked to this mechanism

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