Investigational biologic
ACE-083
An investigational locally acting muscle-growth agent that increased treated-muscle volume in clinical trials but did not consistently improve strength or function.
Evidence confidence
Human
2/5
Some human clinical evidence
1 citation
Animal
Not yet assessed
Trust Engine review pending.
Mechanistic
Not yet assessed
Trust Engine review pending — see editorial links below.
Editorial evidence links exist, but this category has not yet completed Trust Engine assessment.
Safety
2/5
Partially characterised safety
1 citation
Claimed uses
- Moderate
Mechanisms
- not-yet-documented
- Activin type IIB ligand trapping
Safety notes
Injection-site reactions were common. Increasing muscle volume without reliable functional improvement limits clinical relevance. Safety outside controlled trials and product quality in unregulated markets are uncertain.
Regulation
- Not approved for routine clinical use or bodybuilding. Development was discontinued after phase 2 programmes failed to show consistent functional benefit.
References
Last reviewed
11 July 2026