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PeptiBrief
Cosmetic peptide

Acetyl Hexapeptide-1

A cosmetic peptide marketed for tanning, photoprotection and hair repigmentation through alpha-MSH-related melanogenesis. Independent human evidence is sparse.

Evidence confidence

Human
2/5
Some human clinical evidence
1 citation
Animal
Not yet assessed
Trust Engine review pending.
Mechanistic
Not yet assessed
Trust Engine review pending — see editorial links below.
Editorial evidence links exist, but this category has not yet completed Trust Engine assessment.
Safety
Not yet assessed
Trust Engine review pending.

Claimed uses

Mechanisms

Safety notes

Topical irritation or unwanted pigmentation is possible. Evidence is inadequate for treating vitiligo or reversing grey hair, and cosmetic products should not replace medical assessment of pigment disorders.

Regulation
  • Cosmetic ingredient; not an approved medicine for vitiligo, hair greying or other pigment disorders.

References

  1. Case report on premature hair graying treated with Melitane 5% and oral hair supplements · 2019
Last reviewed
11 July 2026
Important PeptiBrief is an educational information platform. It does not diagnose, prescribe, sell peptides, recommend dosing, encourage self-experimentation or replace qualified medical care. Published scientific evidence is kept separate from community observations and uncertainty.