Cosmetic peptide
Acetyl Tetrapeptide-15
A topical cosmetic peptide marketed to reduce skin discomfort and hyperreactivity. Evidence is preliminary and largely supplier-associated.
Evidence confidence
Human
Not yet assessed
Trust Engine review pending.
Animal
Not yet assessed
Trust Engine review pending.
Mechanistic
Not yet assessed
Trust Engine review pending — see editorial links below.
Editorial evidence links exist, but this category has not yet completed Trust Engine assessment.
Safety
Not yet assessed
Trust Engine review pending.
Claimed uses
- Weak
Mechanisms
- not-yet-documented
- Sensory neuropeptide modulation
Safety notes
Topical irritation or sensitisation remains possible. Cosmetic soothing claims should not replace medical assessment of persistent burning, pain or inflammatory skin disease.
Regulation
- Cosmetic ingredient; not an approved analgesic or dermatological medicine.
References
Last reviewed
11 July 2026