Peptide · Cosmetic peptide

Acetyl Tetrapeptide-15

Cosmetic peptide
Aliases · Skinasensil · Acetyl tetrapeptide 15

A topical cosmetic peptide marketed to reduce skin discomfort and hyperreactivity. Evidence is preliminary and largely supplier-associated.

Human
1/5
Animal
0/5
In-vitro
0/5
Safety
0/5
Last reviewed · 7/11/2026
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Last reviewed7/11/2026
Evidence statusEarly entry
Published references0
Trust signal panel
Evidence & safety
  • Human evidence
    n/a
  • Animal evidence
    n/a
  • Mechanistic
    n/a
  • Safety knowledge
    n/a
  • Editorial confidence
    3/5
View in knowledge graph →See this peptide connected to conditions & mechanisms
01

Evidence Snapshot

Evidence snapshot · 1 verified ref
Overall
1/5Insufficient certainty
Human
1/5Only review or summary sources indexed (not counted as primary human evidence)
Animal
0/5None identified
In-vitro
0/5None identified
Safety
0/5None identified
02

Scientific identity

Peptide family
Sensitive-skin neuromodulating peptide
Entity class
Cosmetic peptide
Alternative names
SkinasensilAcetyl tetrapeptide 15
Discovery history

Developed for topical sensitive-skin cosmetics under the trade name Skinasensil, with proposed endorphin-like modulation of neuronal excitability and CGRP release.

02

Proposed Mechanisms

03

Reported / Studied Uses

04

Human Evidence

Review literature cites early in vivo cosmetic testing, but robust independent randomized trials are lacking.

05

Animal Evidence

No robust animal efficacy evidence supporting routine cosmetic use was identified.

Species translation to humans is uncertain.
06

Safety & Unknowns

topical-cosmeticlimited-independent-evidencesensitive-skin-claimformulation-dependent
Topical irritation or sensitisation remains possible. Cosmetic soothing claims should not replace medical assessment of persistent burning, pain or inflammatory skin disease.
07

Regulatory Status

CountryStatusNotes
08

Community Observations

No approved community reports yet. Submit one. Aggregate data is observational only.
09

References

  • No verified references linked yet. Editors will add primary sources.
10

Full Disclaimer

This page is for educational information only. It does not constitute medical advice, diagnosis, treatment, dosing guidance, or a recommendation to use any peptide, medicine or research chemical. Many peptides discussed on Atlas are not approved for human use in most jurisdictions and may have limited or unknown long-term safety data.

Community observations shown on this page are anonymised, moderated and observational only. They do not establish safety or effectiveness.

Always consult a qualified healthcare professional before making decisions about your health. See medical disclaimer and methodology.

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ImportantPeptiBrief is an educational information platform. It does not diagnose, prescribe, sell peptides, recommend dosing, encourage self-experimentation or replace qualified medical care. Published scientific evidence is kept separate from community observations and uncertainty.