Cosmetic peptide
Acetyl Tetrapeptide-5
A cosmetic peptide marketed for under-eye puffiness and dark circles. Independent peptide-specific clinical evidence is insufficient.
Evidence confidence
Human
Not yet assessed
Trust Engine review pending.
Animal
Not yet assessed
Trust Engine review pending.
Mechanistic
Not yet assessed
Trust Engine review pending — see editorial links below.
Editorial evidence links exist, but this category has not yet completed Trust Engine assessment.
Safety
Not yet assessed
Trust Engine review pending.
Claimed uses
- Insufficient
Mechanisms
- not-yet-documented
- Vascular permeability and fluid-balance modulation
Safety notes
Avoid direct eye contact. Irritation, tearing or sensitisation may occur. Persistent or one-sided swelling requires medical assessment rather than cosmetic treatment.
Regulation
- Cosmetic ingredient; not an approved treatment for medical oedema or eye disease.
Last reviewed
11 July 2026