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PeptiBrief
Endogenous peptide hormone

Adrenomedullin

An endogenous 52-amino-acid peptide hormone involved in vascular tone, endothelial integrity, lymphatic biology and inflammatory responses.

Sequence
YRQSMNNFQGLRSFGCRFGTCTVQKLAHQIYQFTDKDKDNVAPRSKISPQGY-NH2
Formula
C203H331N63O60S3
Molecular weight
6028.7 Da

Evidence confidence

Human
2/5
Some human clinical evidence
1 citation
Animal
Not yet assessed
Trust Engine review pending.
Mechanistic
Not yet assessed
Trust Engine review pending — see editorial links below.
Editorial evidence links exist, but this category has not yet completed Trust Engine assessment.
Safety
2/5
Partially characterised safety
1 citation

Claimed uses

Mechanisms

Safety notes

Systemic administration can lower blood pressure and alter fluid, renal and hormonal regulation. Clinical use requires medical monitoring; long-term therapeutic safety is not established.

Regulation
  • No broadly approved adrenomedullin medicine for general cardiovascular, anti-ageing or recovery use. Therapeutic analogues and antibodies remain product- and indication-specific.

References

  1. Current perspective on a peptide hormone with significant therapeutic potential · 2020
  2. Differing thresholds for modulatory effects of adrenomedullin infusion on haemodynamic and hormonal responses to angiotensin II and adrenocorticotrophic hormone in healthy volunteers · 2001
Last reviewed
11 July 2026
Important PeptiBrief is an educational information platform. It does not diagnose, prescribe, sell peptides, recommend dosing, encourage self-experimentation or replace qualified medical care. Published scientific evidence is kept separate from community observations and uncertainty.