Adropin
An endogenous peptide associated with substrate use, endothelial function and cardiometabolic health. Most therapeutic claims remain preclinical.
- Human evidencen/a
- Animal evidencen/a
- Mechanisticn/a
- Safety knowledgen/a
- Editorial confidence4/5
Evidence Snapshot
- Overall
- 2/5Emerging / preliminary
- Human
- 2/5Some human clinical evidence
- Animal
- 2/5Some animal evidence
- In-vitro
- 0/5None identified
- Safety
- 0/5None identified
Scientific identity
- Molecular formula
- C208H346N76O65S2
- Molecular weight
- 4999.7 Da
- Peptide family
- Energy-homeostasis-associated peptide
- Entity class
- Endogenous peptide hormone
- Alternative names
- ENHO proteinAdropin-34-76
Identified in 2008 as an ENHO-encoded factor linking nutrient intake with energy homeostasis and lipid metabolism.
Proposed Mechanisms
- not-yet-documentedpending-editorial-review
- Mitochondrial function →supported
- Nitric oxide / blood flow →supported
Reported / Studied Uses
- Metabolic Health / Insulin ResistanceEvidence · weak
- Mitochondrial functionEvidence · weak
Human Evidence
Human studies are mainly observational and report associations between circulating adropin and endothelial function, diabetes, obesity and cardiovascular phenotypes.
Animal Evidence
Animal experiments support effects on glucose oxidation, fatty-acid use, insulin sensitivity and vascular biology.
Safety & Unknowns
Regulatory Status
| Country | Status | Notes |
|---|
Community Observations
References
- No verified references linked yet. Editors will add primary sources.
Full Disclaimer
This page is for educational information only. It does not constitute medical advice, diagnosis, treatment, dosing guidance, or a recommendation to use any peptide, medicine or research chemical. Many peptides discussed on Atlas are not approved for human use in most jurisdictions and may have limited or unknown long-term safety data.
Community observations shown on this page are anonymised, moderated and observational only. They do not establish safety or effectiveness.
Always consult a qualified healthcare professional before making decisions about your health. See medical disclaimer and methodology.
Explore further
from the knowledge graph- Plasma adropin levels predict endothelial dysfunction like flow-mediated dilatation in patients with type 2 diabetes mellitus2013 · observational_study
- Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism2008 · discovery_and_animal_study