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PeptiBrief
Peptide · Synthetic tetrapeptide

AEDG Peptide

Research peptide
Aliases · Ala-Glu-Asp-Gly · AEDG tetrapeptide

A synthetic tetrapeptide studied in cell, animal and limited human research for gene regulation, circadian biology and cellular ageing. Clinical evidence is insufficient.

Human
0/5
Animal
0/5
In-vitro
3/5
Safety
0/5
Last reviewed · 7/11/2026
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Last reviewed7/11/2026
Evidence statusEarly entry
Published references0
Trust signal panel
Evidence & safety
  • Human evidence
    n/a
  • Animal evidence
    n/a
  • Mechanistic
    n/a
  • Safety knowledge
    n/a
  • Editorial confidence
    2/5
View in knowledge graph →See this peptide connected to conditions & mechanisms
01

Evidence Snapshot

Evidence snapshot · 2 verified refs
Overall
2/5Emerging / preliminary
Human
0/5None identified
Animal
0/5None identified
In-vitro
3/5Multiple mechanistic studies
Safety
0/5None identified
02

Scientific identity

Molecular formula
C15H24N4O9
Molecular weight
404.37 Da
Sequence
Ala-Glu-Asp-Gly
Peptide family
Pineal-derived short peptide
Entity class
Synthetic tetrapeptide
Alternative names
Ala-Glu-Asp-GlyAEDG tetrapeptide
Discovery history

Synthesised as a short tetrapeptide based on amino-acid motifs associated with pineal peptide preparations and studied primarily by a small research network.

02

Proposed Mechanisms

03

Reported / Studied Uses

04

Human Evidence

Limited and methodologically uncertain human studies report circadian or melatonin-related findings. No robust modern randomized evidence establishes anti-ageing or longevity benefits.

05

Animal Evidence

Animal studies report effects on lifespan, circadian biology and age-related physiology, but independent replication is limited.

Species translation to humans is uncertain.
06

Safety & Unknowns

research-onlylongevity-claimslimited-independent-replicationno-established-human-dosing
Long-term safety, carcinogenic risk and consequences of altering telomerase or gene expression are not established. Online products may not match research material.
07

Regulatory Status

CountryStatusNotes
08

Community Observations

No approved community reports yet. Submit one. Aggregate data is observational only.
09

References

  • No verified references linked yet. Editors will add primary sources.
10

Full Disclaimer

This page is for educational information only. It does not constitute medical advice, diagnosis, treatment, dosing guidance, or a recommendation to use any peptide, medicine or research chemical. Many peptides discussed on Atlas are not approved for human use in most jurisdictions and may have limited or unknown long-term safety data.

Community observations shown on this page are anonymised, moderated and observational only. They do not establish safety or effectiveness.

Always consult a qualified healthcare professional before making decisions about your health. See medical disclaimer and methodology.

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ImportantPeptiBrief is an educational information platform. It does not diagnose, prescribe, sell peptides, recommend dosing, encourage self-experimentation or replace qualified medical care. Published scientific evidence is kept separate from community observations and uncertainty.