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PeptiBrief
Endogenous peptide fragment

Angiotensin IV

A short endogenous angiotensin fragment studied mainly for learning, memory, cerebral blood flow and insulin-regulated aminopeptidase biology.

Sequence
Val-Tyr-Ile-His-Pro-Phe
Formula
C40H54N8O8
Molecular weight
774.9 Da

Evidence confidence

Human
Not yet assessed
Trust Engine review pending.
Animal
Not yet assessed
Trust Engine review pending.
Mechanistic
Not yet assessed
Trust Engine review pending — see editorial links below.
Editorial evidence links exist, but this category has not yet completed Trust Engine assessment.
Safety
Not yet assessed
Trust Engine review pending.

Claimed uses

Mechanisms

Safety notes

Human safety, pharmacokinetics and long-term neurological or cardiovascular effects are not established. Unregulated intranasal products may be mislabelled.

Regulation
  • Not approved as a cognitive enhancer or neurological medicine.

References

  1. From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase · 2020
  2. AT4 receptor is insulin-regulated membrane aminopeptidase: potential mechanisms of memory enhancement · 2003
Last reviewed
11 July 2026
Important PeptiBrief is an educational information platform. It does not diagnose, prescribe, sell peptides, recommend dosing, encourage self-experimentation or replace qualified medical care. Published scientific evidence is kept separate from community observations and uncertainty.