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PeptiBrief
Endogenous peptide family

Apelin

A family of endogenous peptides that activate the apelin receptor and regulate cardiovascular function, fluid balance and metabolism.

Evidence confidence

Human
2/5
Some human clinical evidence
1 citation
Animal
Not yet assessed
Trust Engine review pending.
Mechanistic
Not yet assessed
Trust Engine review pending — see editorial links below.
Editorial evidence links exist, but this category has not yet completed Trust Engine assessment.
Safety
Not yet assessed
Trust Engine review pending.

Claimed uses

Mechanisms

Safety notes

Potential risks include hypotension, dizziness and cardiovascular effects. Different apelin isoforms are not interchangeable.

Regulation
  • No broadly approved native apelin medicine for cardiovascular, renal, metabolic or performance use.

References

  1. International Union of Basic and Clinical Pharmacology. CVII. Structure and Pharmacology of the Apelin Receptor with a Recommendation that Elabela/Toddler Is a Second Endogenous Peptide Ligand · 2019
  2. Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist · 2015
Last reviewed
12 July 2026
Important PeptiBrief is an educational information platform. It does not diagnose, prescribe, sell peptides, recommend dosing, encourage self-experimentation or replace qualified medical care. Published scientific evidence is kept separate from community observations and uncertainty.