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PeptiBrief
Peptide · Endogenous peptide hormone

Atrial Natriuretic Peptide

Research peptide
Aliases · ANP · Atrial natriuretic factor · ANF

An endogenous cardiac peptide that promotes natriuresis, vasodilation and suppression of the renin-aldosterone system.

Human
1/5
Animal
0/5
In-vitro
0/5
Safety
0/5
Last reviewed · 7/12/2026
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Last reviewed7/12/2026
Evidence statusEarly entry
Published references0
Trust signal panel
Evidence & safety
  • Human evidence
    n/a
  • Animal evidence
    n/a
  • Mechanistic
    n/a
  • Safety knowledge
    n/a
  • Editorial confidence
    5/5
View in knowledge graph →See this peptide connected to conditions & mechanisms
01

Evidence Snapshot

Evidence snapshot · 1 verified ref
Overall
1/5Insufficient certainty
Human
1/5Only review or summary sources indexed (not counted as primary human evidence)
Animal
0/5None identified
In-vitro
0/5None identified
Safety
0/5None identified
02

Scientific identity

Molecular formula
C127H203N45O39S3
Molecular weight
3080.5 Da
Sequence
SLRRSSCFGGRIDRIGAQSGLGCNSFRY
Peptide family
Natriuretic peptide family
Entity class
Endogenous peptide hormone
Alternative names
ANPAtrial natriuretic factorANF
Discovery history

Discovered as a cardiac hormone released mainly from atrial tissue in response to stretch and volume expansion.

02

Proposed Mechanisms

03

Reported / Studied Uses

04

Human Evidence

Human physiology and clinical biomarker evidence are extensive. Short-acting ANP preparations have been used clinically in limited jurisdictions and settings.

05

Animal Evidence

Animal and laboratory evidence established renal, vascular and endocrine actions.

Species translation to humans is uncertain.
06

Safety & Unknowns

endogenous-hormonehypotension-risknatriuresiselectrolyte-effects
Exogenous ANP can cause hypotension, dizziness, altered renal function and fluid or electrolyte disturbances. Medical monitoring is required.
07

Regulatory Status

CountryStatusNotes
08

Community Observations

No approved community reports yet. Submit one. Aggregate data is observational only.
09

References

  • No verified references linked yet. Editors will add primary sources.
10

Full Disclaimer

This page is for educational information only. It does not constitute medical advice, diagnosis, treatment, dosing guidance, or a recommendation to use any peptide, medicine or research chemical. Many peptides discussed on Atlas are not approved for human use in most jurisdictions and may have limited or unknown long-term safety data.

Community observations shown on this page are anonymised, moderated and observational only. They do not establish safety or effectiveness.

Always consult a qualified healthcare professional before making decisions about your health. See medical disclaimer and methodology.

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ImportantPeptiBrief is an educational information platform. It does not diagnose, prescribe, sell peptides, recommend dosing, encourage self-experimentation or replace qualified medical care. Published scientific evidence is kept separate from community observations and uncertainty.