Research peptide
Epitalon
Epitalon is a research peptide indexed in the PeptiBrief evidence database. It has a defined amino-acid sequence in this dossier.
- Sequence
- AEDG
Evidence confidence
Human
Not yet assessed
Trust Engine review pending — see editorial links below.
Editorial evidence links exist, but this category has not yet completed Trust Engine assessment.
Animal
3/5
Multiple animal studies
2 citations
Mechanistic
2/5
Some mechanistic research
1 citation
Safety
Not yet assessed
Trust Engine review pending.
Claimed uses
- Preclinical + very limited human
- Anecdotal
- Insufficient
- Insufficient
Mechanisms
- Telomerase-related effects
- Melatonin/pineal axis modulation
- Telomerase and chromatin regulation
- Telomere / cellular ageing
Safety notes
Long-term safety, validated dosing and product quality may be uncertain outside formal clinical development.
Regulation
- Not generally licensed as an anti-ageing or longevity medicine.
- Not approved for general wellness or performance use unless a specific regulated product and indication exists.
References
- Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties · 2025
- Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and pancreas in elderly monkeys · 2005
- Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice · 2003
- Peptide Epitalon activates chromatin at the old age · 2003
Last reviewed
12 July 2026