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PeptiBrief
Endogenous neuropeptide

Urocortin

An endogenous CRF-family peptide involved in stress, appetite, endocrine and cardiovascular signalling.

Evidence confidence

Human
2/5
Some human clinical evidence
1 citation
Animal
Not yet assessed
Trust Engine review pending.
Mechanistic
2/5
Some mechanistic research
1 citation
Safety
2/5
Partially characterised safety
1 citation

Claimed uses

Mechanisms

Safety notes

Exogenous urocortin may alter blood pressure, heart rate, endocrine signalling and appetite. Long-term safety is unknown.

Regulation
  • No broadly approved urocortin-1 medicine for stress, metabolic or cardiovascular use.

References

  1. Urocortin-1 infusion in normal humans · 2004
  2. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor · 1995
Last reviewed
12 July 2026
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