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PeptiBrief
Endogenous neuropeptide

Urocortin-III

An endogenous CRF2-selective peptide studied for vascular, cardiac, metabolic and stress-related physiology.

Evidence confidence

Human
3/5
Multiple human studies
2 citations
Animal
Not yet assessed
Trust Engine review pending.
Mechanistic
Not yet assessed
Trust Engine review pending — see editorial links below.
Editorial evidence links exist, but this category has not yet completed Trust Engine assessment.
Safety
2/5
Partially characterised safety
1 citation

Claimed uses

Mechanisms

Safety notes

Possible risks include hypotension, headache, flushing and cardiovascular instability.

Regulation
  • Not approved as a general cardiovascular, metabolic or stress-related medicine.

References

  1. Cardiovascular effects of urocortin 2 and urocortin 3 in patients with chronic heart failure · 2016
  2. Vascular effects of urocortins 2 and 3 in healthy volunteers · 2013
Last reviewed
12 July 2026
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