Condition · Skin, Hair & Cosmetic
Skin Ageing / Wrinkles
00
Background biology
Skin ageing involves collagen and elastin changes, fibroblast activity, oxidative stress, inflammation and cumulative ultraviolet exposure.
01
Evidence-ranked peptides
| Peptide | Use | Evidence |
|---|---|---|
| GHK-Cu GHK-Cu is an investigational peptide, analogue or research construct with evidence ranging from mechanistic studies to limited human trials. | Skin Ageing / Wrinkles insufficient | Human2/5 Animal2/5 Safety2/5 3 verified refs |
| Acetyl Dipeptide-31 Amide A topical cosmetic micropeptide with early laboratory and small clinical evidence for anti-inflammatory, firming and skin-ageing benefits. | Skin Ageing / Wrinkles weak | Human2/5 Animal0/5 Safety0/5 1 verified ref |
| Acetyl Hexapeptide-19 A poorly characterised cosmetic peptide used in anti-ageing formulations. Published evidence specific to acetyl hexapeptide-19 is extremely limited. | Skin Ageing / Wrinkles insufficient | Human2/5 Animal0/5 Safety0/5 1 verified ref |
| BPC-157 BPC-157 is an investigational peptide, analogue or research construct with evidence ranging from mechanistic studies to limited human trials. | Skin Ageing / Wrinkles low | Human1/5 Animal0/5 Safety0/5 2 verified refs |
| Palmitoyl Pentapeptide 4 Palmitoyl Pentapeptide 4 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Oligopeptide 20 Oligopeptide 20 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| sh-Oligopeptide-1 sh-Oligopeptide-1 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Tripeptide 10 Citrulline Tripeptide 10 Citrulline is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Palmitoyl Hexapeptide 12 Palmitoyl Hexapeptide 12 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Copper Peptide Complex Copper Peptide Complex is a non-standard product label rather than one defined molecule; evidence depends on the disclosed ingredients and formulation. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Heptapeptide 7 Heptapeptide 7 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Oligopeptide 24 Oligopeptide 24 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Decapeptide 18 Decapeptide 18 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Tetrapeptide 30 Tetrapeptide 30 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Acetyl Tetrapeptide-2 A cosmetic peptide with in vitro evidence of altered keratinocyte mechanics and structural-gene expression. Reliable human anti-ageing evidence is limited. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 1 verified ref |
| Hexanoyl Dipeptide 3 Hexanoyl Dipeptide 3 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Oligopeptide 54 Oligopeptide 54 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Palmitoyl Tripeptide 38 Palmitoyl Tripeptide 38 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Decapeptide 28 Decapeptide 28 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Hexapeptide 2 Hexapeptide 2 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Palmitoyl Oligopeptide Palmitoyl Oligopeptide is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| sh-Polypeptide-7 sh-Polypeptide-7 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Tripeptide 33 Tripeptide 33 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Tetrapeptide 31 Tetrapeptide 31 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Tripeptide 31 Tripeptide 31 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Palmitoyl Tetrapeptide 72 Palmitoyl Tetrapeptide 72 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Oligopeptide 84 Oligopeptide 84 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Decapeptide 30 Decapeptide 30 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Hexapeptide 60 Hexapeptide 60 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Nonapeptide 5 Nonapeptide 5 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Oligopeptide 90 Oligopeptide 90 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Tetrapeptide 52 Tetrapeptide 52 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Oligopeptide 101 Oligopeptide 101 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Tripeptide 61 Tripeptide 61 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Tetrapeptide 60 Tetrapeptide 60 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Heptapeptide 21 Heptapeptide 21 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Tripeptide 66 Tripeptide 66 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Dermal Peptide Complex Dermal Peptide Complex is a non-standard product label rather than one defined molecule; evidence depends on the disclosed ingredients and formulation. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Oligopeptide-1 (EGF) Oligopeptide-1 (EGF) is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Palmitoyl Tripeptide 1 Palmitoyl Tripeptide 1 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Palmitoyl Tetrapeptide 7 Palmitoyl Tetrapeptide 7 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| sh-Polypeptide-9 sh-Polypeptide-9 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Hexapeptide 11 Hexapeptide 11 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Palmitoyl Tripeptide 5 Palmitoyl Tripeptide 5 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Oligopeptide 34 Oligopeptide 34 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Pentapeptide 18 Pentapeptide 18 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| sh-Polypeptide-1 sh-Polypeptide-1 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Nonapeptide 3 Nonapeptide 3 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Oligopeptide 41 Oligopeptide 41 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Pentapeptide 3 Pentapeptide 3 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Nonapeptide 2 Nonapeptide 2 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Oligopeptide 10 Oligopeptide 10 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Hexapeptide 40 Hexapeptide 40 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Hexapeptide 41 Hexapeptide 41 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Decapeptide 25 Decapeptide 25 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Hexapeptide 52 Hexapeptide 52 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Tripeptide 42 Tripeptide 42 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Oligopeptide 76 Oligopeptide 76 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Acetyl Tetrapeptide-9 A cosmetic peptide marketed for firmness and dermal support. Peptide-specific clinical evidence is sparse and is mainly embedded in multi-ingredient formulations. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Tripeptide 47 Tripeptide 47 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Palmitoyl Pentapeptide 20 Palmitoyl Pentapeptide 20 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Tripeptide 55 Tripeptide 55 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Palmitoyl Tripeptide 60 Palmitoyl Tripeptide 60 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Decapeptide 33 Decapeptide 33 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Copper Peptide Repair Complex Copper Peptide Repair Complex is a non-standard product label rather than one defined molecule; evidence depends on the disclosed ingredients and formulation. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Palmitoyl Pentapeptide 31 Palmitoyl Pentapeptide 31 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Hexapeptide 73 Hexapeptide 73 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Palmitoyl Tripeptide 70 Palmitoyl Tripeptide 70 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| GHK-Cu Topical GHK-Cu Topical is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Acetyl Hexapeptide-8 Acetyl Hexapeptide-8 — Cosmetic peptide. Discussed for Wrinkles. Starter seed record; evidence review pending. | Skin Ageing / Wrinkles limited | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Copper Tripeptide-1 Copper Tripeptide-1 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Tetrapeptide 21 Tetrapeptide 21 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Hexapeptide 9 Hexapeptide 9 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Palmitoyl Dipeptide 5 Palmitoyl Dipeptide 5 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| sh-Polypeptide-11 sh-Polypeptide-11 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Tetrapeptide 14 Tetrapeptide 14 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Palmitoyl Tripeptide 28 Palmitoyl Tripeptide 28 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| sh-Polypeptide-3 sh-Polypeptide-3 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| sh-Polypeptide-19 sh-Polypeptide-19 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Oligopeptide 72 Oligopeptide 72 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Palmitoyl Tripeptide 43 Palmitoyl Tripeptide 43 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Heptapeptide 15 Heptapeptide 15 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Nonapeptide 8 Nonapeptide 8 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Oligopeptide 108 Oligopeptide 108 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Oligopeptide 2 Oligopeptide 2 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Decapeptide 4 Decapeptide 4 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Myristoyl Pentapeptide 17 Myristoyl Pentapeptide 17 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Biotinyl Tripeptide-1 Biotinyl Tripeptide-1 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Nonapeptide 1 Nonapeptide 1 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Decapeptide 12 Decapeptide 12 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Tripeptide 29 Tripeptide 29 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| sh-Polypeptide-22 sh-Polypeptide-22 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Palmitoyl Tetrapeptide 20 Palmitoyl Tetrapeptide 20 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Tripeptide 1 Tripeptide 1 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Myristoyl Hexapeptide 16 Myristoyl Hexapeptide 16 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Oligopeptide 68 Oligopeptide 68 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Tripeptide 30 Tripeptide 30 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Palmitoyl Tetrapeptide 50 Palmitoyl Tetrapeptide 50 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Pentapeptide 48 Pentapeptide 48 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Hexapeptide 20 Hexapeptide 20 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Nonapeptide 4 Nonapeptide 4 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Copper Peptide Blend Copper Peptide Blend is a non-standard product label rather than one defined molecule; evidence depends on the disclosed ingredients and formulation. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Hexapeptide 53 Hexapeptide 53 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Tetrapeptide 44 Tetrapeptide 44 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Copper Peptide Serum Complex Copper Peptide Serum Complex is a non-standard product label rather than one defined molecule; evidence depends on the disclosed ingredients and formulation. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Hexapeptide 65 Hexapeptide 65 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Palmitoyl Hexapeptide 19 Palmitoyl Hexapeptide 19 is used or marketed in cosmetic formulations, with evidence that is usually formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Hexapeptide 71 Hexapeptide 71 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Tetrapeptide 58 Tetrapeptide 58 is used or marketed in cosmetic formulations, with evidence that is generally formulation-dependent and rarely peptide-isolated. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
| Hexapeptide 77 Hexapeptide 77 is used or marketed in topical cosmetic formulations, with peptide-specific clinical evidence that is limited or formulation-dependent. | Skin Ageing / Wrinkles insufficient | Human0/5 Animal0/5 Safety0/5 0 verified refs |
02
Current standard management
conventional medicineSun protection, topical retinoids and evidence-based dermatological care have stronger clinical foundations than many peptide claims.
Medical disclaimer —Standard-of-care information is educational only. Do not change or start treatment based on Atlas content. Always consult a qualified clinician for personal medical decisions.
04
Linked mechanisms
biological pathways discussed for this condition- Collagen synthesisneeds review
- Fibroblast activityneeds review
- Extracellular matrix remodellingneeds review
- Wound repairneeds review
- Inflammation modulationneeds review
- Oxidative stressneeds review
- Extracellular matrix remodellinglimited
- Skin inflammation and extracellular matrix modulationpreliminary
- Keratinocyte mechanics and structural-protein modulationlimited
- Collagen synthesislimited
- Wound repairlimited
- Angiogenesislimited
05
Research gaps
what we don't know yet- ·Few large independent peptide trials
- ·Formulation and route differ
- ·Long-term injectable safety is poorly characterized
03
Community observations
No approved community reports for this condition yet. Submit one.
Clinician discussion
Questions you can ask a qualified clinician
- What are the established evidence-based options for this condition?
- What monitoring is appropriate before considering any experimental intervention?
- What long-term safety data exists for peptide-based approaches?
- Are there licensed medicines relevant to my situation?
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from the knowledge graphPeptides that touch this
Mechanisms in play