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PeptiBrief
Research peptide

GHK-Cu

GHK-Cu is a research peptide indexed in the PeptiBrief evidence database.

Evidence confidence

Human
2/5
Some human clinical evidence
1 citation
Animal
3/5
Multiple animal studies
3 citations
Mechanistic
Not yet assessed
Trust Engine review pending — see editorial links below.
Editorial evidence links exist, but this category has not yet completed Trust Engine assessment.
Safety
2/5
Partially characterised safety
1 citation

Claimed uses

Mechanisms

Safety notes

Long-term safety, validated dosing and product quality may be uncertain outside formal clinical development.

Regulation
  • Commonly used as a cosmetic ingredient; medicinal and injectable claims require jurisdiction-specific review.
  • Not approved for general wellness or performance use unless a specific regulated product and indication exists.

References

  1. Are We Ready to Measure Skin Permeation of Modern Antiaging GHK-Cu Tripeptide Encapsulated in Liposomes? · 2025
  2. The glycyl-l-histidyl-l-lysine-Cu(2+) tripeptide complex attenuates lung inflammation and fibrosis in silicosis by targeting peroxiredoxin 6 · 2024
  3. Glycyl-L-histidyl-L-lysine-Cu(2+) attenuates cigarette smoke-induced pulmonary emphysema and inflammation by reducing oxidative stress pathway · 2022
  4. GHK-Cu-liposomes accelerate scald wound healing in mice · 2017
  5. The human tri-peptide GHK and tissue remodeling · 2008
  6. Effects of topical copper tripeptide complex on CO2 laser-resurfaced skin · 2006
Last reviewed
12 July 2026
Important PeptiBrief is an educational information platform. It does not diagnose, prescribe, sell peptides, recommend dosing, encourage self-experimentation or replace qualified medical care. Published scientific evidence is kept separate from community observations and uncertainty.