Animal study· 1988
Potent antinociceptive effect of centrally administered delta-sleep-inducing peptide (DSIP)
Nakamura A; Nakashima M; Sugao T; Kanemoto H; Fukumura Y; Shiomi H
European journal of pharmacology
- PubMed
- 2853064
- Evidence level
- preclinical
- Verification
- verified
Summary
Nakamura et al. 1988 report that ICV/intracisternal DSIP produces a dose-dependent antinociceptive effect in mice and rats in tail-pinch and hot-plate tests, that intrathecal DSIP is inactive, that the effect is blocked by naloxone, and that DSIP has no antinociceptive effect in morphine-tolerant mice — consistent with a supraspinal opioid-mediated mechanism.
Limitations
Rodent model only; older methodology (1988); no per-arm sample sizes in abstract; blinding not described; behavioural nociception readouts subject to observer bias.