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PeptiBrief
Narrative review· 2022

Stress, kisspeptin, and functional hypothalamic amenorrhea

Meczekalski B; Niwczyk O; Bala G; Szeliga A

Current opinion in pharmacology

DOI
10.1016/j.coph.2022.102288
PubMed
36103784
Evidence level
review
Verification
verified

Summary

Meczekalski et al. 2022 review (Curr Opin Pharmacol) synthesising the neuroendocrine mechanisms linking chronic stress, kisspeptin, and CRH to functional hypothalamic amenorrhea (FHA), and discussing kisspeptin-receptor agonists as a candidate therapy for the hypoestrogenic complications of FHA.

Limitations

Narrative synthesis; not a systematic review; no meta-analysis; cites primary trials but does not itself add new efficacy data.

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