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PeptiBrief
Peptide · Endogenous peptide

Kisspeptin

Endogenous peptide
Aliases · Kisspeptin-10 · kisspeptin-54 · KISS1 · Kisspeptin-54 · KISS1 peptide · Metastin

Kisspeptin is an endogenous signalling peptide with physiological relevance; therapeutic administration remains molecule- and indication-specific.

Human
3/5
Animal
0/5
In-vitro
0/5
Safety
3/5
Last reviewed · 7/12/2026
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Last reviewed7/12/2026
Evidence statusEarly entry
Published references0
Trust signal panel
Evidence & safety
  • Human evidence
    n/a
  • Animal evidence
    n/a
  • Mechanistic
    n/a
  • Safety knowledge
    n/a
  • Editorial confidence
    4/5
View in knowledge graph →See this peptide connected to conditions & mechanisms
01

Evidence Snapshot

Evidence snapshot · 3 verified refs
Overall
3/5Moderate certainty (with caveats)
Human
3/5Multiple human studies
Animal
0/5None identified
In-vitro
0/5None identified
Safety
3/5Reasonable safety characterisation
02

Scientific identity

Peptide family
Endogenous signalling peptide
Entity class
Endogenous peptide
Alternative names
Kisspeptin-10kisspeptin-54KISS1Kisspeptin-54KISS1 peptideMetastin
Discovery history

Kisspeptin entered research, clinical or commercial use through investigation of its proposed biological, cosmetic or therapeutic activity.

02

Proposed Mechanisms

03

Reported / Studied Uses

04

Human Evidence

Human evidence supports physiological relevance, but evidence for exogenous treatment varies considerably.

05

Animal Evidence

Animal studies expand understanding of receptor, neural, metabolic or cardiovascular functions.

Species translation to humans is uncertain.
06

Safety & Unknowns

research-stagelimited-long-term-dataendogenous-peptidephysiological-signallingindication-specific
Exogenous administration can produce systemic effects and requires indication-specific dosing and monitoring.
07

Regulatory Status

CountryStatusNotes
08

Community Observations

No approved community reports yet. Submit one. Aggregate data is observational only.
09

References

  • No verified references linked yet. Editors will add primary sources.
10

Full Disclaimer

This page is for educational information only. It does not constitute medical advice, diagnosis, treatment, dosing guidance, or a recommendation to use any peptide, medicine or research chemical. Many peptides discussed on Atlas are not approved for human use in most jurisdictions and may have limited or unknown long-term safety data.

Community observations shown on this page are anonymised, moderated and observational only. They do not establish safety or effectiveness.

Always consult a qualified healthcare professional before making decisions about your health. See medical disclaimer and methodology.

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ImportantPeptiBrief is an educational information platform. It does not diagnose, prescribe, sell peptides, recommend dosing, encourage self-experimentation or replace qualified medical care. Published scientific evidence is kept separate from community observations and uncertainty.