Randomized placebo controlled human pharmacology study· 2025
Sex-dependent increases in oxytocin levels in response to intravenous kisspeptin in humans
Galbiati F; Plessow F; Plummer L; Campbell MB; Nazarloo S; Carter CS
European journal of endocrinology
- PubMed
- 39965102
- Evidence level
- moderate
- Verification
- verified
Summary
Single-arm pharmacology study registered as NCT00914823: an IV bolus of kisspeptin-112-121 in 12 healthy adults raised serum oxytocin 18.8% at 10 minutes, with a much larger rise in males than females.
Limitations
Very small sample (n=12, NCT00914823); not blinded; no placebo arm; single-dose acute pharmacodynamic outcome only; oxytocin assay variability not fully quantified.