Randomized controlled trial· 2010
Effects of Tesamorelin, a Growth Hormone-Releasing Factor, in HIV-Infected Patients with Abdominal Fat Accumulation: A Randomized Placebo-Controlled Trial with a Safety Extension
Falutz J, Potvin D, Mamputu JC, et al.
Journal of Clinical Endocrinology and Metabolism
- PubMed
- 20101189
- Evidence level
- high
- Verification
- verified
Summary
Randomized placebo-controlled study with an extension evaluating tesamorelin in adults living with HIV who had excess abdominal fat accumulation.
Limitations
The indication-specific population limits generalization to ordinary obesity. Effects on visceral fat diminish after discontinuation, and glucose-related and neoplasm-related precautions are important.