Randomized controlled trial· 2010

Effects of Tesamorelin, a Growth Hormone-Releasing Factor, in HIV-Infected Patients with Abdominal Fat Accumulation: A Randomized Placebo-Controlled Trial with a Safety Extension

Falutz J, Potvin D, Mamputu JC, et al.

Journal of Clinical Endocrinology and Metabolism

DOI
10.1210/jc.2009-1170
PubMed
20101189
Evidence level
high
Verification
verified

Summary

Randomized placebo-controlled study with an extension evaluating tesamorelin in adults living with HIV who had excess abdominal fat accumulation.

Limitations

The indication-specific population limits generalization to ordinary obesity. Effects on visceral fat diminish after discontinuation, and glucose-related and neoplasm-related precautions are important.

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