In vitro reproducibility study· 2014
Mechano-growth factor peptide, the COOH terminus of unprocessed insulin-like growth factor 1, has no apparent effect on myoblasts or primary muscle stem cells
Fornaro M, Hinken AC, Needle S, et al.
American Journal of Physiology-Endocrinology and Metabolism
- PubMed
- 24253050
- Evidence level
- laboratory
- Verification
- verified
Summary
Independent laboratory evaluation of native and stabilised synthetic MGF peptides in mouse and human muscle-cell systems.
Limitations
Laboratory systems cannot exclude every possible tissue context, formulation or delivery effect, but directly challenge prominent mechanistic claims.