in_vitro_human_cell_study · 2011
Mechano Growth Factor E peptide, derived from an isoform of IGF-1, activates human muscle progenitor cells and induces an increase in their fusion potential at different ages
Kandalla PK, Goldspink G, Butler-Browne G, Mouly V · Mechanisms of Ageing and Development
laboratoryDOI · 10.1016/j.mad.2011.02.007PMID · 21354439Verified
Plain-English summary
The peptide altered proliferation and fusion-related behaviour in cultured human muscle precursor cells, but this was not a clinical trial and does not show that injected MGF builds or repairs muscle in people.
Population
Cultured human muscle progenitor cells from neonatal, young-adult and older-adult donors
Intervention
Synthetic MGF E-domain peptide exposure
Outcomes measured
Cell proliferation|Senescence|Differentiation|Fusion potential
Key findings
MGF E-domain peptide increased proliferative lifespan and altered fusion-related responses in some donor-age groups.
Limitations
In vitro design, limited donor samples, uncertain translation to intact human tissue and later reproducibility concerns.Risk of bias
Moderate to high for clinical inference — laboratory study with no patient outcomes.Citation
Kandalla PK, Goldspink G, Butler-Browne G, Mouly V (2011). Mechano Growth Factor E peptide, derived from an isoform of IGF-1, activates human muscle progenitor cells and induces an increase in their fusion potential at different ages. Mechanisms of Ageing and Development. https://doi.org/10.1016/j.mad.2011.02.007
Linked peptides in the PeptiBrief database