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Evidence Library
in_vitro_stem_cell_study · 2020

AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism

Khavinson V|Linkova N|Diatlova A|Trofimova S · Molecules
mechanisticDOI · 10.3390/molecules25030609PMID · 32019204Verified
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Plain-English summary

AEDG altered selected neurogenesis-related molecular markers in cultured cells, but this does not establish cognitive or anti-ageing benefits in people.

Population
Human periodontal ligament stem cells in culture
Intervention
AEDG peptide exposure during neuronal differentiation
Outcomes measured
Gene expression|Protein synthesis|Neuronal differentiation markers
Key findings
Reported changes in selected genes and proteins associated with neuronal differentiation.
Limitations
Cell-culture study|No clinical outcomes|Multiple molecular endpoints|Independent replication limited
Risk of bias
Moderate for exploratory laboratory findings; high if extrapolated to human treatment.
Citation
Khavinson V|Linkova N|Diatlova A|Trofimova S (2020). AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules. https://doi.org/10.3390/molecules25030609
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