discovery_and_animal_study · 2008

Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism

preclinicalDOI · 10.1016/j.cmet.2008.10.011PMID · 19041763Verified

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Plain-English summary

Animal and cellular experiments linked adropin with dietary fuel use, lipid metabolism and glucose regulation.

Population

Mouse models and cellular systems

Intervention

Genetic and experimental manipulation of adropin signalling

Outcomes measured

Energy homeostasis|Glucose regulation|Lipid metabolism|Body-weight phenotypes

Key findings

Established adropin as a metabolically responsive peptide hormone in experimental models.

Limitations

Predominantly animal and mechanistic work|Does not establish therapeutic efficacy or dosing in humans

Risk of bias

Moderate — extensive discovery work but mainly preclinical.

Citation

Kumar KG|Trevaskis JL|Lam DD|Sutton GM|Koza RA|Chouljenko VN|Kousoulas KG|Rogers PM|Kesterson RA|Thearle M|Ferrante AW Jr|Mynatt RL|Burris TP|Dong JZ|Halem HA|Culler MD|Heisler LK|Stephens JM|Butler AA (2008). Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell Metabolism. https://doi.org/10.1016/j.cmet.2008.10.011

Linked peptides in the PeptiBrief database

→ Adropin