Ⓐ
PeptiBrief
Evidence Library
animal_and_cell_study · 2015

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

Lee C|et al. · Cell Metabolism
preclinicalDOI · 10.1016/j.cmet.2015.02.009PMID · 25738459Verified
View source
Plain-English summary

MOTS-c improved metabolic measures and insulin sensitivity in mouse experiments.

Population
Cell models and mice
Intervention
MOTS-c
Outcomes measured
Glucose metabolism|insulin sensitivity|obesity-related measures
Key findings
Supported a role in mitochondrial-to-nuclear metabolic signalling.
Limitations
Predominantly cell and mouse evidence|Does not establish injected treatment benefit in humans
Risk of bias
Moderate preclinical risk.
Citation
Lee C|et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism. https://doi.org/10.1016/j.cmet.2015.02.009
Linked peptides in the PeptiBrief database
ImportantPeptiBrief is an educational information platform. It does not diagnose, prescribe, sell peptides, recommend dosing, encourage self-experimentation or replace qualified medical care. Published scientific evidence is kept separate from community observations and uncertainty.