MOTS-c
MOTS-c is an investigational peptide, analogue or research construct with evidence ranging from mechanistic studies to limited human trials.
- Human evidencen/a
- Animal evidencen/a
- Mechanisticn/a
- Safety knowledgen/a
- Editorial confidence3/5
Evidence Snapshot
- Overall
- 2/5Emerging / preliminary
- Human
- 2/5Some human clinical evidence
- Animal
- 2/5Some animal evidence
- In-vitro
- 0/5None identified
- Safety
- 0/5None identified
Scientific identity
- Sequence
- MRWQEMGYIFYPRKLR
- Peptide family
- Investigational peptide or analogue
- Entity class
- Research peptide
- Alternative names
- MOTS-c peptideMitochondrial open reading frame of the 12S rRNA-c
MOTS-c entered research, clinical or commercial use through investigation of its proposed biological, cosmetic or therapeutic activity.
Proposed Mechanisms
- AMPK activationin-vitro / preclinical
- Metabolic homeostasis modulationpreclinical
- Mitochondrial-derived peptide signalling →supported
- Mitochondrial function →supported
Reported / Studied Uses
- Healthy ageingEvidence · preclinical
- Metabolic supportEvidence · preclinical
- Longevity / Healthy AgeingEvidence · limited
- Metabolic Health / Insulin ResistanceEvidence · insufficient
- Mitochondrial functionEvidence · insufficient
Human Evidence
Human evidence is absent, limited, early phase or indication-specific.
Animal Evidence
Animal evidence may support biological activity but does not establish clinical efficacy.
Safety & Unknowns
Regulatory Status
| Country | Status | Notes |
|---|---|---|
| Global | Not authorised | Research use only. |
Community Observations
References
Full Disclaimer
This page is for educational information only. It does not constitute medical advice, diagnosis, treatment, dosing guidance, or a recommendation to use any peptide, medicine or research chemical. Many peptides discussed on Atlas are not approved for human use in most jurisdictions and may have limited or unknown long-term safety data.
Community observations shown on this page are anonymised, moderated and observational only. They do not establish safety or effectiveness.
Always consult a qualified healthcare professional before making decisions about your health. See medical disclaimer and methodology.
Explore further
from the knowledge graph- Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans2021 · human_observational_exercise_study
- MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism2016 · narrative_review
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance2015 · animal_and_cell_study