Research peptide
MOTS-c
MOTS-c is a research peptide indexed in the PeptiBrief evidence database. It has a defined amino-acid sequence in this dossier.
- Sequence
- MRWQEMGYIFYPRKLR
Evidence confidence
Human
2/5
Some human clinical evidence
1 citation
Animal
2/5
Some animal evidence
1 citation
Mechanistic
2/5
Some mechanistic research
1 citation
Safety
Not yet assessed
Trust Engine review pending.
Claimed uses
- Preclinical
- Preclinical
- Limited
- Insufficient
- Insufficient
Mechanisms
- AMPK activation
- Metabolic homeostasis modulation
- Mitochondrial-derived peptide signalling
- Mitochondrial function
Safety notes
Long-term safety, validated dosing and product quality may be uncertain outside formal clinical development.
Regulation
- Research.
- Research-stage peptide without general approval for metabolic, exercise or longevity treatment.
- Not approved for general wellness or performance use unless a specific regulated product and indication exists.
References
- MOTS-c Levels and Sarcopenia Risk in Chronic Peritoneal Dialysis Patients: A Pilot Study · 2025
- MOTS-c modulates skeletal muscle function by directly binding and activating CK2 · 2024
- MOTS-c Functionally Prevents Metabolic Disorders · 2023
- Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases · 2023
- Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans · 2021
- MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism · 2016
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance · 2015
Last reviewed
12 July 2026