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PeptiBrief
Evidence Library
narrative_review · 2016

MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism

Lee C|Kim KH|Cohen P · Free Radical Biology and Medicine
reviewPMID · 27216708Verified
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Plain-English summary

Summarises early evidence linking MOTS-c to skeletal muscle, glucose metabolism, obesity and exercise.

Population
Laboratory and animal literature
Intervention
MOTS-c
Outcomes measured
Metabolism|exercise|obesity|ageing pathways
Key findings
Biologically promising, but clinical therapeutic evidence remained absent.
Limitations
Narrative review based mainly on emerging preclinical evidence.
Risk of bias
Moderate-to-high for clinical inference.
Citation
Lee C|Kim KH|Cohen P (2016). MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radical Biology and Medicine
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