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PeptiBrief
Evidence Library
randomized_crossover_trial · 2023

Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder

Mills EG, et al. · JAMA Network Open
moderatePMID · 36735255Trial · isrctn17271094Verified
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Plain-English summary

Kisspeptin altered sexual brain processing and increased experimental measures of arousal in a small short-term study.

Population
Men with HSDD
Sample size
32
Intervention
Kisspeptin versus placebo
Outcomes measured
Functional neuroimaging, penile tumescence and psychometric outcomes
Key findings
Supports research interest, not established routine treatment.
Limitations
Small sample, acute administration and surrogate/experimental outcomes.
Risk of bias
Moderate; randomized crossover design but small sample.
Citation
Mills EG, et al. (2023). Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder. JAMA Network Open
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