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PeptiBrief
Evidence Library
narrative_review · 2017

Topical peptides as cosmeceuticals

Pai VV|Bhandari P|Shukla P · Indian Journal of Dermatology, Venereology and Leprology
weak
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Plain-English summary

The review explains why acetyl hexapeptide-1 is marketed for skin tanning and hair repigmentation, but it does not establish strong clinical efficacy.

Population
Cosmetic dermatology literature
Intervention
Topical cosmetic peptides
Outcomes measured
Proposed mechanisms|Cosmetic applications|Available efficacy evidence
Key findings
Acetyl hexapeptide-1 was described as influencing melanin production through alpha-MSH-related signalling.
Limitations
Narrative review|Limited primary human evidence|Commercial ingredient claims may underpin some mechanisms
Risk of bias
High — narrative review with heterogeneous and often low-level source evidence.
Citation
Pai VV|Bhandari P|Shukla P (2017). Topical peptides as cosmeceuticals. Indian Journal of Dermatology, Venereology and Leprology
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