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Evidence Library
discovery_and_receptor_characterisation · 1995

Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor

Vaughan J|Donaldson C|Bittencourt J|Perrin MH|Lewis K|Sutton S|Chan R|Turnbull AV|Lovejoy D|Rivier C|Rivier J|Sawchenko PE|Vale W · Nature
preclinicalPMID · 7477349Verified
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Plain-English summary

This was the landmark discovery paper establishing urocortin as a distinct CRF-family peptide.

Population
Mammalian tissue and receptor systems
Intervention
Cloning and pharmacological characterisation of urocortin
Outcomes measured
Peptide identity|Distribution|CRF receptor binding|Biological activity
Key findings
Established urocortin as an endogenous high-affinity CRF-family ligand.
Limitations
Discovery and preclinical characterisation|No therapeutic outcomes
Risk of bias
Low for molecular discovery; not applicable to clinical efficacy.
Citation
Vaughan J|Donaldson C|Bittencourt J|Perrin MH|Lewis K|Sutton S|Chan R|Turnbull AV|Lovejoy D|Rivier C|Rivier J|Sawchenko PE|Vale W (1995). Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature
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