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PeptiBrief
Evidence Library
human_vascular_pharmacology_study · 2013

Vascular effects of urocortins 2 and 3 in healthy volunteers

Venkatasubramanian S|Grieve DJ|MacLeod KT|Webb DJ|Newby DE · Journal of the American Heart Association
moderatePMID · 23525432Verified
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Plain-English summary

Both peptides caused potent and prolonged arterial vasodilation in humans.

Population
Healthy volunteers
Intervention
Local arterial infusion of urocortin-2 or urocortin-3
Outcomes measured
Forearm blood flow|Vasodilation|Tachyphylaxis
Key findings
Confirmed prolonged CRF2-mediated vasodilation.
Limitations
Small physiology study|Local vascular endpoints|No disease outcome data
Risk of bias
Moderate for clinical translation; lower for acute vascular target engagement.
Citation
Venkatasubramanian S|Grieve DJ|MacLeod KT|Webb DJ|Newby DE (2013). Vascular effects of urocortins 2 and 3 in healthy volunteers. Journal of the American Heart Association
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