Metabolic and neuroendocrine
Amylin receptor signalling
Activation of amylin receptors influences satiation, food intake, gastric emptying and post-meal glucagon secretion through hindbrain and peripheral pathways.
Biological pathway
Amylin receptor agonism at calcitonin-receptor and receptor-activity-modifying-protein complexes → hindbrain satiation signalling → reduced energy intake and altered gastric and glucagon responses.
Evidence summary
Amylin biology is established, and clinical trials of long-acting analogues support effects on appetite and body weight.
Limitations
The contribution of individual receptor subtypes and the long-term balance of efficacy and tolerability remain incompletely defined for investigational analogues.