Amylin receptor signalling
Activation of amylin receptors influences satiation, food intake, gastric emptying and post-meal glucagon secretion through hindbrain and peripheral pathways.
Biological pathway
Amylin receptor agonism at calcitonin-receptor and receptor-activity-modifying-protein complexes → hindbrain satiation signalling → reduced energy intake and altered gastric and glucagon responses.
Evidence summary
Amylin biology is established, and clinical trials of long-acting analogues support effects on appetite and body weight.
Limitations
Peptides linked to this mechanism
A class of amylin-receptor agonists that slow gastric emptying, suppress post-meal glucagon and increase satiety. Evidence and regulatory status vary substantially by molecule.
Cagrilintide is an investigational peptide, analogue or research construct with evidence ranging from mechanistic studies to limited human trials.